Question

Which enzyme is responsible for cleaning neurotransmitters in the synaptic cleft?

• A. Acetylcholinesterase
• B. DNA polymerase
• C. RNAase
• D. Lipase

Hint:

Inhibition of acetylcholinesterase is a common mechanism of action for certain nerve agents and pesticides, leading to the accumulation of acetylcholine and continuous nerve signal transmission.

Answer 1

The Correct Option is A

Acetylcholinesterase is the enzyme responsible for breaking down the neurotransmitter acetylcholine in the synaptic cleft. By hydrolyzing acetylcholine into acetate and choline, acetylcholinesterase terminates the signal transmission between neurons, ensuring that neurotransmitters do not remain in the synaptic cleft longer than necessary. This rapid degradation is essential for the proper functioning of synaptic transmission and prevents continuous stimulation of the post-synaptic neuron.
Role of Acetylcholinesterase: \[ \text{Acetylcholine} \xrightarrow{\text{Acetylcholinesterase}} \text{Acetate} + \text{Choline} \] 

Importance in Neural Function: Efficient clearance of neurotransmitters like acetylcholine is vital for: Preventing overstimulation of neurons. Ensuring precise control of muscle contractions. Maintaining the speed and accuracy of nerve signal transmission. 

Conclusion: Acetylcholinesterase plays a critical role in terminating neurotransmitter signals, thereby maintaining the efficiency and regulation of neural communication.