Question

Which among the following anticoagulants is synthesized using Michael condensation?

• A. \( \text{Phenindione} \)
• B. \( \text{Warfarin} \)
• C. \( \text{Dicoumarol} \)
• D. \( \text{Bromindione} \)

Hint:

Think of the synthesis of coumarin-based anticoagulants like warfarin involving carbon-carbon bond formation through Michael addition.

Answer 1

The Correct Option is B

Warfarin is synthesized through a process that involves a Michael addition reaction (also known as Michael condensation) as a key step. This reaction involves the nucleophilic addition of a carbanion or another nucleophile to an $\alpha,\beta$-unsaturated carbonyl compound. The synthesis of warfarin involves the Michael addition of a phenoxide ion to 3-oxo-1-phenylbutyl benzoate.