Question

What will be change observed in liquid chromatography with increased mobile phase flow rate?

• A. Decreased pressure
• B. Increased resolution
• C. Increased sensitivity
• D. Reduced retention times

Hint:

Higher flow rate = faster elution = shorter retention time (but potentially lower resolution).

Answer 1

The Correct Option is D

When the mobile phase flow rate increases in liquid chromatography, analytes move through the column more quickly. This leads to reduced retention times, although it may compromise resolution and sensitivity.