Question

What is the major product of Carbylamine reaction?

• A. Cyanide
• B. Isocyanide
• C. Nitrite
• D. Alkane

Answer 1

The Correct Option is B

The Carbylamine reaction, also known as the isocyanide test or Hofmann isocyanide synthesis, is an important reaction in organic chemistry used to synthesize isocyanides. In this reaction, a primary amine reacts with chloroform in the presence of a strong base like potassium hydroxide (KOH), leading to the formation of an isocyanide (RNC) as the major product. The reaction can be summarized as follows: 

\(RNH_2+CHCl_3+3KOH→RNC+3KCl+3H_2O\)

The products are isocyanide (RNC), potassium chloride (KCl), and water (H₂O). The unique and characteristic foul smell of isocyanides makes this reaction a useful qualitative test for primary amines; however, it only works with aliphatic primary amines, not aromatic amines or secondary/tertiary amines.

In conclusion, among the given options, the major product of the Carbylamine reaction is isocyanide.

Answer 2

The Carbylamine reaction involves the reaction of a primary amine (R-NH₂) with chloroform (CHCl₃) in the presence of a strong base (usually KOH). The reaction leads to the formation of an isocyanide (also known as isocyanate or carbylamine).

• Isocyanides (or isocyanates) have the general structure R-N=C, where the nitrogen is directly attached to a carbon atom with a double bond.

In this reaction:

• A primary amine reacts with chloroform (CHCl₃) and KOH, producing an isocyanide or carbylamine as the major product.

Thus, the major product is isocyanide (Option B).