What are the various routes by which transmission of human immunodeficiency virus takes place?
AIDS (Acquired Immuno Deficiency Syndrome) is caused by the Human immunodeficiency virus (HIV). It has the following modes of transmission
(a) Unprotected sexual contact with an infected person.
(b) Transfusion of blood from a healthy to an infected person.
(c) Sharing infected needles and syringes.
(d) From an infected mother to a child through the placenta
Read the following passage and answer the questions that follow. Prevention is the frontline response to drug use. Effective interventions address the underlying conditions contributing to drug use, such as a lack of connection to family or community, instability, insecurity, trauma, mental health issues, etc. When addressed, these factors can effectively prevent the initiation of drug use and the progression to drug use disorders. Study the few key figures of drug use given below and answer the questions that follow. 
(a) What do you infer from the figures in Table No. 1 about the people with drug use disorders, 2022 (in million)? State any two of your observations.
(b) How are Hepatitis C and HIV related to drug use disorders by people, as shown in Table No. 2? State the correlation between the two.
(c)
"There is widely spatial variation in different sectors of work participation in India." Evaluate the statement with suitable examples.
Alexia Limited invited applications for issuing 1,00,000 equity shares of ₹ 10 each at premium of ₹ 10 per share.
The amount was payable as follows:
Applications were received for 1,50,000 equity shares and allotment was made to the applicants as follows:
Category A: Applicants for 90,000 shares were allotted 70,000 shares.
Category B: Applicants for 60,000 shares were allotted 30,000 shares.
Excess money received on application was adjusted towards allotment and first and final call.
Shekhar, who had applied for 1200 shares failed to pay the first and final call. Shekhar belonged to category B.
Pass necessary journal entries for the above transactions in the books of Alexia Limited. Open calls in arrears and calls in advance account, wherever necessary.
On $31^{\text {st }}$ March, 2024, following is the Balance Sheet of Bhavik Limited :
Bhavik Ltd.
Balance Sheet as at $31^{\text {st }}$ March 2024
I. Equity and Liabilities :
| Particulars | Note No. | $31-3-2024$ (₹) | $31-3-2023$ (₹) |
| 1. Shareholders funds | |||
| (a) Share Capital | 12,00,000 | 10,00,000 | |
| (b) Reserves and Surplus | 1 | 4,00,000 | 3,00,000 |
| 2. Non-current liabilities | |||
| Long-term borrowings | 2 | 6,00,000 | 10,00,000 |
| 3. Current Liabilities | 5,00,000 | 1,00,000 | |
| (a) Trade Payables | 3 | 3,00,000 | 4,00,000 |
| (b) Short-term provisions | |||
| Total | 30,00,000 | 28,00,000 |
II. Assets :
| 1. Non-current Assets | |||
| (a) Property, Plant and Equipment and Intangible Assets | |||
| Property plant and equipment | 4 | 19,00,000 | 15,00,000 |
| (b) Non-current Investments | 3,00,000 | 4,00,000 | |
| 2. Current Assets | |||
| (a) Inventories | 4,50,000 | 3,50,000 | |
| (b) Trade Receivables | 2,50,000 | 4,50,000 | |
| (c) Cash and Cash Equivalents | 1,00,000 | 1,00,000 | |
| Total | 30,00,000 | 28,00,000 |
Notes to Accounts :
| Note | Particulars | $31-3-2024$ (₹) | $31-3-2023$ (₹) |
| No. | |||
| 1. | Reserves and Surplus i.e. Balance in Statement of Profit and Loss | 4,00,000 | 3,00,000 |
| 2. | Long-term borrowings | ||
| 10% Debentures | 6,00,000 | 10,00,000 | |
| 3. | Short-term provisions | ||
| Provision for tax | 3,00,000 | 4,00,000 | |
| 4. | Property plant and equipment | ||
| Plant and Machinery | 21,50,000 | 16,00,000 | |
| Less : Accumulated Depreciation | 2,50,000 | 1,00,000 | |
| 19,00,000 | 15,00,000 |
Additional Information :
Calculate :
Immunity can be defined as the body's ability to guard itself against disease-causing organisms. In other words, it is the ability to resist infection by the action of particular antibodies. Our body has the ability to produce antibodies against pathogens and defend itself from diseases; therefore, we may come in contact with several viruses every day, but not get ill. This defense mechanism is therefore known as immunity.
The immunity, which is present in an organism by birth is called innate Immunity. Innate immunity refers to the body’s defence system. For example, the skin, the barrier of the human body functions by protecting the entry of germs and other disease-causing pathogens.
An individual acquires immunity after birth, hence is called adaptive or acquired immunity. Adaptive immunity develops throughout our lives. We acquire adaptive immunity when we are exposed to infectious diseases and allergies or when we are immunized against them with vaccines.
Passive immunity is developed by antibodies that are produced outside the body. This immunity lasts for a short time. For example, antibodies present in a mother’s breast milk provide a baby with temporary immunity against the diseases.
Active immunity is a type of adaptive immunity, which is developed due to the production of antibodies in one’s own body. This type of immunity occurs when we are in contact with the pathogen or its antigen.