Question

Variation in sensitivity of response to different doses of a drug in different individual is obtained from?

• A. Dose response curve
• B. Therapeutic index
• C. Bioavailability
• D. Phase 1 clinical trials

Answer 1

The Correct Option is A

The variation in sensitivity of response to different doses of a drug in different individuals is obtained from the dose-response curve. A dose-response curve is a graphical representation that illustrates the effect of various doses of a drug on a group of individuals. This curve helps determine:

• Effective Doses: The minimum dose that produces the desired effect.
• Toxic Doses: The dose at which adverse effects occur.
• Potency: The amount of drug required to produce an effect of a given intensity.
• Efficacy: The maximum effect a drug can achieve, regardless of dose.

Such curves enable researchers to understand the variability in drug response across a population, assess the therapeutic window, and guide dosage recommendations.