Question

Type II hypersensitivity:

• A. Is antibody independent
• B. Is complement independent
• C. Is mediated by CD8+ cells
• D. Involves antibody-mediated destruction of cells

Answer 1

The Correct Option is D

Step 1: Understanding Type II hypersensitivity. - Type II hypersensitivity is an antibody-mediated reaction where IgG or IgM antibodies target specific cells, leading to cell destruction. - This destruction occurs via complement activation, opsonization, or antibody-dependent cellular cytotoxicity (ADCC). 

Step 2: Explanation of incorrect options. - Antibody independent (A): Incorrect because antibodies (IgG, IgM) play a central role in this reaction. 
- Complement independent (B): Incorrect because complement activation contributes to cell lysis. 
- Mediated by CD8+ cells (C): Incorrect because CD8+ T cells are involved in Type IV hypersensitivity, not Type II. 

Step 3: Selecting the correct option. Since Type II hypersensitivity is characterized by antibody-mediated destruction of cells, the correct answer is (D) Involves antibody-mediated destruction of cells.