Question

Coomb's test is used for detection of:

• A. \( \text{Yellow fever} \)
• B. \( \text{Syphilis} \)
• C. \( \text{Typhoid} \)
• D. \( \text{Antiglobulin} \)

Hint:

The Coomb's test is essential in blood transfusion compatibility testing and diagnosing autoimmune conditions like hemolytic anemia.

Answer 1

The Correct Option is D

Step 1: Understanding the Coomb's test. The Coomb's test, also known as the antiglobulin test, is used to detect antibodies or complement proteins that are bound to the surface of red blood cells. It is primarily used in immunohematology. 

Step 2: Types of Coomb's test. - Direct Coomb's Test (DCT): Detects antibodies bound to red blood cells in conditions like hemolytic anemia or hemolytic disease of the newborn. - Indirect Coomb's Test (ICT): Detects antibodies in the serum, such as those present in transfusion reactions or during pregnancy. 

Step 3: Comparison with other options. - Option \( (A) \): Yellow fever is detected by serological tests or PCR, not Coomb's test. 
- Option \( (B) \): Syphilis is detected using tests like VDRL or TPHA. 
- Option \( (C) \): Typhoid is diagnosed using the Widal test or blood culture. 

Conclusion: The Coomb's test is specifically used for the detection of \( \text{antiglobulin} \), making \( (D) \) the correct answer.