Question

True about colchicines is/are?

• A. Acts by neutrophil recruitment
• B. Causes metaphase arrest
• C. Useful in urate-lowering therapy
• D. All of the above

Answer 1

The Correct Option is D

Colchicine is a medication used primarily for its anti-inflammatory properties, especially in the management of gout. It functions in the following key ways:

• Acts by neutrophil recruitment: Colchicine disrupts the inflammatory process by inhibiting neutrophil chemotaxis and activity. This reduces the inflammatory response in conditions like acute gout.
• Causes metaphase arrest: Colchicine binds to tubulin, preventing its polymerization into microtubules, which in turn disrupts mitosis by arresting cells in metaphase. This property has been traditionally used in cytogenetics for chromosome analysis.
• Useful in urate-lowering therapy: While colchicine itself does not lower uric acid levels, it is effective in controlling the inflammation and pain associated with gout flares, often used in conjunction with urate-lowering medications.
• All of the above: Given colchicine's multiple modes of action and applications in the inflammatory response, mitosis disruption, and gout treatment, all the provided statements about colchicine are true.