Question

Transplantation of tissues/organs to save certain patients often fails due to rejection of such tissues/organs by the patient. Which type of immune response is responsible for such rejections?

• A. Auto-immune response
• B. Humoral immune response
• C. Physiological immune response
• D. Cell-mediated immune response

Hint:

Humoral immunity involves B-cells and antibodies in the blood, while Cell-mediated immunity involves T-cells and is the main culprit in organ rejection.

Answer 1

The Correct Option is D

Step 1: When an organ is transplanted, the recipient's immune system identifies the new tissue as "non-self" or foreign.
Step 2: The Cell-mediated immune response (CMI), involving T-lymphocytes, is primarily responsible for detecting these foreign antigens on the graft.
Step 3: T-cells then attack and destroy the transplanted cells, leading to graft rejection. This is why immunosuppressants are required for life after a transplant.