Question

The term “bioisosterism” in drug design aims to maintain or improve the molecule's biological activity by:

• A. Replacement of a functional group with another that enhances lipophilicity
• B. Replacement of a chemical group in a molecule with another that has similar physical and chemical properties
• C. Structural modification to increase water solubility
• D. Conversion of a drug into a salt form

Hint:

Bioisosterism = similar properties → retained or enhanced biological activity.

Answer 1

The Correct Option is B

Bioisosterism involves the substitution of an atom or group in a molecule with another that has similar physical or chemical properties to achieve similar biological effects. This approach helps in improving the pharmacokinetic or pharmacodynamic profile of a drug without altering its core activity.