Step 1: Understanding ozone layer depletion.
The ozone layer is crucial for protecting the Earth from harmful ultraviolet (UV) radiation. Some chemicals, especially chlorofluorocarbons (CFCs), have been found to cause significant depletion of the ozone layer.
Step 2: Analyzing the options.
- (A) CFC: Correct. CFCs are man-made compounds that, when released into the atmosphere, break down ozone molecules, leading to the depletion of the ozone layer.
- (B) $CH_{4}$: Methane (CH4) is a potent greenhouse gas but is not responsible for ozone depletion.
- (C) DDT: DDT is a pesticide, and while it is harmful to the environment, it is not the primary cause of ozone depletion.
- (D) $O_{3}$: Ozone itself is the substance in the ozone layer, and it is being depleted, not the cause of the depletion.
Step 3: Conclusion.
The correct answer is (A) CFC, as these chemicals are primarily responsible for ozone layer depletion.