Question

The preservative suitable for use in ophthalmic preparations is _______

• A. \( \text{Sodium benzoate} \)
• B. \( \text{Chlorobutanol} \)
• C. \( \text{Benzoic acid} \)
• D. \( \text{Butyl hydroxyl anisole} \)

Hint:

Remember that ophthalmic preservatives need to be gentle on the eye. Chlorobutanol is a frequent choice due to its balance of efficacy and tolerability.

Answer 1

The Correct Option is B

Ophthalmic preparations require preservatives that are effective against a broad spectrum of microorganisms but are also non-irritating and safe for use in the eye. Chlorobutanol is a commonly used preservative in ophthalmic formulations due to its effectiveness, relative non-irritancy at appropriate concentrations (typically 0.5%), and stability. Sodium benzoate and benzoic acid can be used as preservatives, but their effectiveness is pH-dependent, and they can be irritating to the eye. Butyl hydroxyl anisole (BHA) is an antioxidant and is not typically used as an antimicrobial preservative in ophthalmic preparations.