Question

The patient is having a headache and confusion. A brain tumor diagnosis is made. Family history reveals brain and kidney tumors. Choose the correct option.

• A. Neurofibromatosis
• B. Li fraumeni syndrome
• C. VHL syndrome
• D. Churg Strauss syndrome

Hint:

In cases of familial brain and kidney tumors, consider VHL syndrome, especially when hemangioblastomas or renal cell carcinoma are involved.

Answer 1

The Correct Option is C

Von Hippel-Lindau (VHL) syndrome is a genetic condition characterized by the development of multiple tumors, including brain and kidney tumors, which match the symptoms described in this patient. The key features of VHL syndrome are hemangioblastomas in the brain, retinal angiomas, and renal cell carcinoma. This syndrome is associated with mutations in the VHL gene, which is involved in tumor suppression. The patient's family history of brain and kidney tumors further supports this diagnosis. - Neurofibromatosis is characterized by skin nodules and other types of tumors, but it does not typically cause brain and kidney tumors in the same way. - Li fraumeni syndrome is characterized by an increased risk of a variety of cancers, but brain and kidney tumors are not the hallmark. - Churg Strauss syndrome is an autoimmune condition affecting blood vessels, often presenting with asthma and eosinophilia, which is not consistent with the symptoms here.