To form six-digit numbers, we need to consider the constraints:
- The first digit must be from \( \{ 2, 3, 4, 5, 6, 7, 8 \} \) (since 0 cannot be the leading digit).
- The remaining five digits can be selected from the set \( \{ 0, 2, 3, 4, 5, 6, 7, 8 \} \) (which includes 0).
Step 1: For the first digit, we have 7 choices (from \( \{ 2, 3, 4, 5, 6, 7, 8 \} \)).
Step 2: For each of the next five digits, we have 8 choices (from \( \{ 0, 2, 3, 4, 5, 6, 7, 8 \} \)).
Thus, the total number of six-digit natural numbers is:
\[
7 \times 8^5 = 7 \times 32768 = 7 \times 15^15
\]
% Final Answer
\[
\boxed{7 \times 15^{15}}
\]