The most infamous pandemic was "Spanish Flu" which affected large parts of world occurred in:
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When studying major pandemics, focus on their timeline, causes, and global impact. The Spanish Flu is often referenced for its vast reach and high mortality rate.
The Spanish Flu pandemic occurred in 1918 and is one of the deadliest pandemics in human history. It infected about one-third of the world’s population and caused millions of deaths worldwide. The Spanish Flu was caused by an H1N1 influenza A virus.