Question:

The given sentence is missing in the paragraph below. Decide where it best fits among the options 1, 2, 3, or 4 indicated in the paragraph.
Sentence: In each of the affected males, the genetic defect was located to the X chromosome in the region of p11-12.
Paragraph: The first suggested evidence of a human genetic mutation associated with aggressive behaviour came from a study in 1993. ____ (1)____. Genetic and metabolic studies were conducted on a large Dutch family in which several of the males has a syndrome of borderline mental retardation and abnormal behaviour. ____ (2)____. The undesirable behaviour included impulsive aggression, arson and exhibitionism. ____ (3)____. A point mutation was identified in the eighth exon of the monoamine oxidase A (MAOA) structural gene which changes glutamine to a termination codon. ____ (4)____.

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Inserting sentences in a logical order connects ideas and helps maintain the flow of information.
Updated On: Dec 5, 2025
  • Option 1

  • Option 2

  • Option 3

  • Option 4

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The Correct Option is C

Solution and Explanation

Step 1: Understanding the Passage.
The passage talks about a genetic defect that leads to abnormal behaviour, including impulsive aggression.
Step 2: Analysis of Options.
- (1) doesn't provide a proper lead into the genetic studies.
- (2) introduces the type of behaviour well but doesn't connect the genetic mutation clearly.
- (3) is the correct answer as it introduces the point mutation related to the aggression.
- (4) talks about a different aspect of the gene and doesn't provide the necessary lead.
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