Question:

The given sentence is missing in the paragraph below. Decide where it best fits among the options 1, 2, 3, or 4 indicated in the paragraph.
Sentence: In each of the affected males, the genetic defect was located to the X chromosome in the region of p11-12.
Paragraph: The first suggested evidence of a human genetic mutation associated with aggressive behaviour came from a study in 1993. ____ (1)____. Genetic and metabolic studies were conducted on a large Dutch family in which several of the males has a syndrome of borderline mental retardation and abnormal behaviour. ____ (2)____. The undesirable behaviour included impulsive aggression, arson and exhibitionism. ____ (3)____. A point mutation was identified in the eighth exon of the monoamine oxidase A (MAOA) structural gene which changes glutamine to a termination codon. ____ (4)____.

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Inserting sentences in a logical order connects ideas and helps maintain the flow of information.
Updated On: Jan 5, 2026
  • Option 1

  • Option 2

  • Option 3

  • Option 4

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The Correct Option is C

Approach Solution - 1

To determine the best placement for the given sentence within the paragraph, we need to understand the flow and context of the information provided. The sentence discusses a genetic defect located on the X chromosome in affected males. Let's analyze the paragraph:

The paragraph starts by mentioning a study in 1993 related to human genetic mutation and aggressive behavior. The next sentence introduces the context of the study, which includes genetic and metabolic studies on a Dutch family. This provides a setting for the investigation.

The third part, currently having the placeholder (2), discusses the undesirable behaviors observed. This sequence naturally follows the introduction of the study’s context.

The missing sentence, "In each of the affected males, the genetic defect was located to the X chromosome in the region of p11-12", fits well after the sentence describing the undesirable behaviors observed in the family. This is because it provides a crucial detail about the genetic finding related to the behaviors described.

The next sentence elaborates on the nature of the mutation identified, which flows logically after specifying the chromosome region involved.

Thus, the sequence should be:

  • Introduction of the study (1993 study related to genetic mutation)
  • Context of the study (about the Dutch family)
  • Details of the observed behaviors
  • The genetic location of the defect that explains these behaviors ("In each of the affected males, the genetic defect was located to the X chromosome in the region of p11-12")
  • Identification of the type of mutation

After analyzing this structure, it becomes clear that the given sentence logically fits at option 3, right before the discussion of the point mutation.

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Approach Solution -2

To determine where the given sentence best fits within the paragraph, we need to evaluate the logical flow and content of the paragraph and the specific details of the sentence itself.

The given sentence is: "In each of the affected males, the genetic defect was located to the X chromosome in the region of p11-12."

Let's break down the paragraph:

  1. Sentence (1): Introducing a study from 1993 that suggested a link between human genetic mutation and aggressive behavior. This sentence serves as an introductory statement.
  2. Sentence (2): Discusses the study conducted on a large Dutch family with several males exhibiting certain behaviors. It continues from the introduction, focusing on the demographics and symptoms of the subjects in the study.
  3. Sentence (3): (missing): This is where we evaluate the fit for the given sentence about locating the genetic defect. It connects the specific details about the genetic mutation discovered in the subjects.
  4. Sentence (4): Describes the specific genetic mutation identified, providing a molecular detail that follows logically after introducing the presence of a genetic defect.

The correct placement for the missing sentence is at position (3). Here's why:

  • The paragraph flows logically by first introducing the study, describing the subjects' characteristics and behavior, then specifying the genetic anomaly linked to their behavior.
  • Sentence (3) ideally should bridge the description of the subjects' characteristics and the specific genetic findings, which the given sentence does by pointing out the genetic defect's specific location on the X chromosome.

By placing the sentence in option (3), the paragraph maintains a clear and logical progression from the study's introduction through to the detailed findings. Therefore, the correct answer is Option 3.

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