Question

The given image is an x-ray of a 22-year-old female. What is the probable diagnosis?

• A. Chondroblastoma
• B. Osteochondroma
• C. Giant cell tumor
• D. Aneurysmal bone cyst

Answer 1

The Correct Option is C

The given x-ray is indicative of a Giant Cell Tumor (GCT), which is most commonly diagnosed in young adults aged 20-40 years. This condition is characterized by several distinct features:

• Location: Giant cell tumors typically occur in the epiphysis of long bones, with a predilection for regions around the knee, such as the distal femur or proximal tibia.
• Appearance: They appear as circumscribed lytic lesions with a defined border but without a sclerotic rim. The tumors are locally aggressive and may extend to subarticular bone.
• Symptoms: Patients often present with pain and swelling in the affected area. As the tumor grows, it may cause structural weakness, leading to fractures.

In comparison to the other options provided:

• Chondroblastoma: Also occurs in young adults but typically presents in the epiphysis. However, it often has calcifications visible on x-ray, not characteristic of GCT.
• Osteochondroma: A benign bone growth often presented as an exostosis with a cartilage cap. They usually occur on the metaphysis, not epiphysis.
• Aneurysmal Bone Cyst: An expansile, blood-filled cystic lesion often metaphyseal and characterized by a "soap bubble" appearance, which is distinguishable from GCT.

Based on the typical age and radiographic presentation described, the most probable diagnosis is Giant Cell Tumor.