This is a much more doable question. Sentence 3 says ‘fish skin swims in here…’. To swim in here means to come and fill a gap or fulfil a role. 4 says that because there are risks in collagen proteins derived from pigs and cows, they cannot be used in the medial field. 3 says fish skin swims in here and fills the gap. Thus 43 form a pair. 2 is the opening sentence because it discusses collagen in general talks about its function. Both 3 and 1 talk about fish collagen and form a pair. The right sequence is 2431.