Question:

The five sentences (labelled 1,2,3,4, and 5) given in this question, when properly sequenced, form a coherent paragraph. Decide on the proper order for the sentence and key in this sequence of five numbers as your answer. 
1. Scientists have for the first time managed to edit genes in a human embryo to repair a genetic mutation, fuelling hopes that such procedures may one day be available outside laboratory conditions. 
2.The cardiac disease causes sudden death in otherwise healthy young athletes and affects about one in 500 people overall. 
3. Correcting the mutation in the gene would not only ensure that the child is healthy but also prevents transmission of the mutation to future generations. 
4. It is caused by a mutation in a particular gene and a child will suffer from the condition even if it inherits only one copy of the mutated gene. 
5. In results announced in Nature this week, scientists fixed a mutation that thickens the heart muscle, a condition called hypertrophic cardiomyopathy.

Updated On: Jul 30, 2025
  • 15243
  • 12543
  • 15423
  • 24315
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The Correct Option is A

Solution and Explanation

To determine the correct sequence of the sentences to form a coherent paragraph, we need to identify the logical flow:
  • Sentence 1: Introduces the breakthrough in gene editing in human embryos.
  • Sentence 5: Expands on the findings by mentioning the specific mutation corrected, associated with hypertrophic cardiomyopathy.
  • Sentence 2: Provides further context about the cardiac disease, mentioning its impact on young athletes and prevalence.
  • Sentence 4: Details the genetic cause of the condition and its inheritance.
  • Sentence 3: Explains the overall goal of correcting the mutation for health benefits and preventing future transmission.
Thus, the sequences naturally connect within the framework: the scientific achievement leads to specific discoveries, explains the condition's significance, dives into genetic causes, and finishes with potential long-term impacts. The proper order is 15243.
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