Question

The final stage of peptidoglycan (PG) biosynthesis is marked by PG cross-link formation and remodeling. Which of the following enzymes does NOT take part in these processes?

• A. Transglycosidases
• B. Transpeptidases
• C. Transaminases
• D. DD-carboxypeptidases

Hint:

Transpeptidases (penicillin-binding proteins) are key targets of β-lactam antibiotics.

Answer 1

The Correct Option is C

Step 1: Recall peptidoglycan biosynthesis.
- Transglycosidases: Link glycan chains.
- Transpeptidases: Cross-link peptide chains.
- DD-carboxypeptidases: Modify cross-links in PG remodeling.
Step 2: Exclude non-participant.
Transaminases are involved in amino acid metabolism, not in PG cross-linking or remodeling.
Final Answer: \[ \boxed{\text{Transaminases do not participate in peptidoglycan biosynthesis.}} \]