Question

The distance between the bottom of the dissolution flask and bottom tip of the paddle in a dissolution apparatus according to Indian Pharmacopoeia is _______ cm.

• A. \( 2.3 \pm 0.2 \)
• B. \( 2.5 \pm 0.2 \)
• C. \( 2.7 \pm 0.2 \)
• D. \( 2.9 \pm 0.2 \)

Hint:

Remember the standard distance of $2.5 \pm 0.2$ cm for the paddle/basket height in dissolution testing as per major pharmacopoeias.

Answer 1

The Correct Option is B

According to the Indian Pharmacopoeia (IP) and also the United States Pharmacopeia (USP), the distance between the bottom of the dissolution flask and the bottom tip of the paddle (or basket) in a standard dissolution apparatus (Apparatus 1 or Apparatus 2) is maintained at $2.5 \pm 0.2$ cm. This specific distance is crucial for ensuring consistent hydrodynamic conditions within the dissolution vessel, which directly affects the drug dissolution rate. Maintaining this standard distance helps in obtaining reproducible and reliable dissolution data.