Question:
The disease sickle cell anemia is caused by substitution of 'A' by 'B' of 'C' globin chain of hemoglobin molecule. Identify A, B and C respectively
The disease sickle cell anemia is caused by substitution of 'A' by 'B' of 'C' globin chain of hemoglobin molecule. Identify A, B and C respectively
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Remember the amino acid change Glutamic acid → Valine in β-globin for sickle cell anemia. It's a classic example of point mutation causing genetic disease.
Updated On: Oct 27, 2025
- A-Alanine, B-Glutamic acid, C-Beta
- A-Glutamic acid, B-Valine, C-Beta
- A-Valine, B-Glutamic acid, C - Alpha
- A-Valine, B - Serine, C-Beta
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The Correct Option is B
Solution and Explanation
Sickle cell anemia arises due to a single amino acid substitution in the β-globin chain of hemoglobin: Glutamic acid (hydrophilic) is replaced by Valine (hydrophobic) at position 6. This leads to abnormal hemoglobin (HbS) and sickling of RBCs.
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