Question

Tadalafil should not be given with:

• A. Vasodilator
• B. Antibiotics
• C. Vasoconstrictors
• D. Valproate

Answer 1

The Correct Option is A

Tadalafil is a medication primarily used in the treatment of erectile dysfunction and works as a phosphodiesterase type 5 (PDE5) inhibitor. It functions by dilating blood vessels, which increases blood flow to certain areas of the body.

When considering drug interactions, it's crucial to understand that combining tadalafil with other vasodilators can lead to an excessive drop in blood pressure. Vasodilators are drugs that widen blood vessels, thereby lowering blood pressure.

Administering tadalafil along with vasodilators could result in severe hypotension (low blood pressure), which can be dangerous and lead to symptoms like dizziness, fainting, and in severe cases, shock.

Therefore, tadalafil should not be given with vasodilators due to the risk of compounded vasodilatory effects that can significantly lower blood pressure.

Option	Reason for Avoidance
Vasodilator	Can cause severe hypotension when combined with tadalafil.
Antibiotics	No significant interactions with tadalafil.
Vasoconstrictors	Opposite effect of tadalafil; not typically contraindicated.
Valproate	No direct interaction with tadalafil.

Based on the interaction profile of tadalafil, the correct answer is Vasodilator.