We are given that \( \frac{x + y}{xy} \) is a positive integer. Let this value be \( k \).
Then:
\[
\frac{x + y}{xy} = k x + y = kxy \tag{1}
\]
Rewriting this:
\[
kxy - x - y = 0 1 = kxy - x - y \tag{2}
\]
This is equivalent to solving:
\[
kxy - x - y = 1
\]
Try small positive integer values for \( x \), \( y \), and \( k \), but this equation never holds true for distinct positive integers.
For example, try \( x = 1, y = 1 \):
\[
\frac{1 + 1}{1} = 2 \text{integer, but } x = y \text{ (not distinct)}
\]
Try \( x = 2, y = 1 \frac{3}{2} = 1.5 \) — not an integer.
This pattern continues. Every time we test for distinct \( x, y \), the result is either not an integer or violates the equation.
Conclusion: No such pair of distinct positive integers satisfies the condition.
\[
\boxed{\text{Never possible}}
\]