Question

Site of action of amphotericin B is:

• A. Ribosomes
• B. Cell wall
• C. Plasma membrane
• D. Protein

Answer 1

The Correct Option is B

In the context of pharmacology, understanding the mechanism of action of antifungal agents is crucial. Amphotericin B is a well-known antifungal medication used to treat severe fungal infections. The question here pertains to the primary site of action of amphotericin B, with the options provided:

• Ribosomes
• Cell wall
• Plasma membrane
• Protein

Correct Answer: Plasma membrane

Explanation:

• Amphotericin B is a polyene antifungal known for its action on the fungal cell membrane, not the cell wall. It binds to ergosterol, a key component of the fungal cell membrane.
• Upon binding to ergosterol, amphotericin B forms pores in the cell membrane. These pores disrupt the cell membrane's integrity, leading to leakage of essential intracellular components and ultimately causing cell death.
• This mechanism distinguishes amphotericin B from other antifungals that may target different sites such as the cell wall or intracellular processes.

Therefore, the statement that amphotericin B acts on the cell wall is incorrect. The correct site of action is indeed the plasma membrane.