Question

Select the INCORRECT statement with respect to the SAR of adrenergic agonists with specific reference to 3’,5’-dihydroxy ring substitution pattern.

• A. Increases the drug distribution
• B. Increases resistance to metabolism by COMT
• C. Provides selectivity for \(\beta_2\)-receptors
• D. Orally active bronchodilator

Hint:

3’,5’-dihydroxy → rapid metabolism → reduced oral activity and distribution.

Answer 1

The Correct Option is A

The 3’,5’-dihydroxy substitution on the aromatic ring leads to rapid metabolism by COMT and poor oral bioavailability. Therefore, it limits drug distribution rather than increasing it, making option (1) incorrect.