Question

Regulatory B cells (Bregs) are important mediators of adaptive immunity and function mainly via the secretion of:

• A. IL-10
• B. IL-2
• C. TNF-alpha
• D. IFN-gamma

Hint:

IL-10 is the key cytokine secreted by regulatory B cells (Bregs) that helps in immune regulation by suppressing pro-inflammatory responses and promoting immune tolerance.

Answer 1

The Correct Option is A

Step 1: Understand Regulatory B cells (Bregs).
Regulatory B cells (Bregs) are a specialized subset of B-cells that help control immune responses and maintain immune system balance. They play a vital role in suppressing inflammation and preventing autoimmune reactions.

Step 2: Evaluate the cytokines involved in Breg function.

• IL-10: Correct. IL-10 is the signature cytokine of Bregs. It inhibits the function of pro-inflammatory cells such as Th1, Th17, and antigen-presenting cells. IL-10 is central to the immune-suppressive activity of Bregs.
• IL-2: Involved in T-cell proliferation and function. Not secreted by Bregs.
• TNF-alpha: A pro-inflammatory cytokine secreted mainly by macrophages and T-cells. Not characteristic of Bregs.
• IFN-gamma: Produced by T-cells and NK cells to activate macrophages and promote inflammation. Not a Breg cytokine.

Step 3: Conclusion.
Regulatory B cells exert their immune-suppressive effects primarily through the secretion of IL-10.

Correct Answer: Option (1)