Step 1: Understanding Nonsense Mutation
A nonsense mutation introduces a premature stop codon in the mRNA sequence, leading to incomplete or truncated protein synthesis.
Step 2: Evaluating Other Options
- Mutation of promoter region: Affects transcription initiation, not directly related to premature protein synthesis.
- Missense mutation: Leads to an amino acid change but not premature termination.
- Frameshift mutation: Alters the reading frame, but does not necessarily cause premature termination.
Step 3: Conclusion
Nonsense mutation is the primary cause of premature or incomplete protein synthesis.
A closed-loop system has the characteristic equation given by: $ s^3 + k s^2 + (k+2) s + 3 = 0 $.
For the system to be stable, the value of $ k $ is: