Step 1: Understanding Nonsense Mutation
A nonsense mutation introduces a premature stop codon in the mRNA sequence, leading to incomplete or truncated protein synthesis.
Step 2: Evaluating Other Options
- Mutation of promoter region: Affects transcription initiation, not directly related to premature protein synthesis.
- Missense mutation: Leads to an amino acid change but not premature termination.
- Frameshift mutation: Alters the reading frame, but does not necessarily cause premature termination.
Step 3: Conclusion
Nonsense mutation is the primary cause of premature or incomplete protein synthesis.