Question

Positive acid schiff macrophages seen in ?

• A. Whipples disease
• B. Crohns disease
• C. AIDS
• D. None of the above

Answer 1

The Correct Option is A

Whipple's disease is a rare systemic infectious disease caused by the bacterium Tropheryma whipplei. It primarily affects the small intestine but can involve any part of the body.

One characteristic feature of Whipple's disease is the presence of positive acid-Schiff (PAS) staining macrophages in tissue sections. The macrophages containing this bacterium exhibit a granular and positively staining reaction when subjected to PAS staining due to the abundant glycoprotein content in the infected macrophages.

Among the given options:

• Whipple's disease: Shows PAS-positive macrophages in the lamina propria of the small intestine.
• Crohn's disease: Does not typically present with PAS-positive macrophages as seen in Whipple's disease.
• AIDS: While it can lead to various opportunistic infections, it does not specifically show PAS-positive macrophages as a feature.
• None of the above: Incorrect as Whipple's disease is known for this feature.

Hence, the correct answer is Whipple's disease.