Question

'Philadelphia chromosome' is NOT linked to

• A. cancer
• B. hyperactive tyrosine kinase
• C. chromosomal aberration
• D. Down's syndrome

Hint:

The Philadelphia chromosome is linked to leukemia and is associated with a genetic mutation involving chromosome 22, not Down's syndrome.

Answer 1

The Correct Option is D

Step 1: Understanding the Philadelphia chromosome.
The Philadelphia chromosome is a genetic abnormality associated with chronic myelogenous leukemia (CML). It results from a translocation between chromosomes 9 and 22, leading to the formation of a fusion gene that encodes a hyperactive tyrosine kinase, which contributes to the uncontrolled cell division seen in cancer.

Step 2: Analyzing the options.
(A)cancer: Correct — The Philadelphia chromosome is linked to cancer, particularly chronic myelogenous leukemia (CML).
(B)hyperactive tyrosine kinase: Correct — The Philadelphia chromosome causes the production of a hyperactive tyrosine kinase, which is central to its role in cancer.
(C)chromosomal aberration: Correct — The Philadelphia chromosome is a chromosomal aberration that leads to cancer.
(D)Down's syndrome: Incorrect — Down's syndrome is caused by a trisomy of chromosome 21, not by the Philadelphia chromosome.

Step 3: Conclusion.
The correct answer is (D)Down's syndrome, as it is not linked to the Philadelphia chromosome.