Question

PDE 4 inhibitor used in COPD

• A. Montelukast
• B. Roflumilast
• C. Cromoglicate
• D. Omalizumab

Hint:

PDE4 inhibitors like roflumilast help control inflammation in COPD by modulating intracellular signaling pathways, improving symptoms and reducing exacerbations.

Answer 1

The Correct Option is B

Phosphodiesterase-4 (PDE4) inhibitors are a class of drugs that reduce inflammation by preventing the breakdown of cyclic AMP (cAMP) in inflammatory cells. - Roflumilast is a selective PDE4 inhibitor approved for use in chronic obstructive pulmonary disease (COPD). By inhibiting PDE4, it increases intracellular cAMP levels, leading to reduced release of pro-inflammatory mediators.
- This results in decreased inflammation in the lungs, improved airflow, and reduced exacerbations in COPD patients.
- Other options: - Montelukast is a leukotriene receptor antagonist used in asthma, not a PDE4 inhibitor.
- Cromoglicate (cromolyn sodium) is a mast cell stabilizer used in asthma prophylaxis.
- Omalizumab is an anti-IgE monoclonal antibody used for allergic asthma.
Hence, roflumilast is the correct PDE4 inhibitor used in COPD management.