Question

Match the following drugs and their Mechanism of Action (MOA):

• A. (1)-(R), (2)-(S), (3)-(P), (4)-(Q)
• B. (1)-(Q), (2)-(S), (3)-(P), (4)-(R)
• C. (1)-(R), (2)-(Q), (3)-(P), (4)-(S)
• D. (1)-(Q), (2)-(R), (3)-(S), (4)-(P)

Hint:

Understanding drug mechanisms is vital for rational therapy and predicting adverse effects or resistance mechanisms in tuberculosis treatment.

Answer 1

The Correct Option is A

This matching involves understanding the mechanisms of action (MOA) of key anti-tubercular drugs used in the treatment of tuberculosis: \begin{itemize} \item Ethambutol — Inhibits arabinosyl transferase, an enzyme essential for the polymerization of arabinogalactan, a crucial component of the mycobacterial cell wall. (1)-(R)
\item Para-aminosalicylic acid (PAS) — Acts as a structural analog of PABA and inhibits folate synthase, thereby interfering with folate metabolism. (2)-(S)
\item Rifampicin — Inhibits DNA-dependent RNA polymerase in mycobacteria, preventing transcription and RNA synthesis. (3)-(P)
\item Bedaquiline — Specifically targets and inhibits the mycobacterial ATP synthase enzyme, leading to depletion of cellular energy (ATP) in Mycobacterium tuberculosis. (4)-(Q)
\end{itemize} Matching accordingly: - (1)-(R) Ethambutol
- (2)-(S) Para-aminosalicylic acid
- (3)-(P) Rifampicin
- (4)-(Q) Bedaquiline