Question

Which of the following anticancer drugs produces hand-foot syndrome?

• A. Methotrexate
• B. Capecitabine
• C. Vincristine
• D. Doxorubicin

Hint:

Hand-foot syndrome is a distinctive dermatological toxicity of capecitabine and some other fluoropyrimidines; early recognition helps in effective management and dose modification.

Answer 1

The Correct Option is B

Hand-foot syndrome, also known as palmar-plantar erythrodysesthesia, is a common adverse effect associated with certain chemotherapeutic agents. It is characterized by redness, swelling, pain, and peeling of the skin on the palms of the hands and soles of the feet. - Capecitabine is an oral prodrug of 5-fluorouracil (5-FU) widely used in cancer chemotherapy. It is well known to cause hand-foot syndrome as a dose-limiting toxicity. The syndrome results from the drug’s effect on rapidly dividing skin cells and capillary damage in the extremities. - Other drugs listed, such as Methotrexate, Vincristine, and Doxorubicin, have different toxicity profiles but are not commonly associated with hand-foot syndrome. Management of hand-foot syndrome includes dose adjustment, symptomatic treatment with emollients, and sometimes corticosteroids.