Question

One of the following is correct match or mechanisms select it :

• A. Methotrexate-Inhibition of microtubules, Vinca alkaloids-Inhibition of Purine synthesis, Bleomycin- Inhibitors of RNA, 5-Fluoro Uracil-DNA damage
• B. Methotrexate-DNA damage, Vinca alkaloids-Inhibition of microtubules, Bleomycin-Inhibitors of 2- deoxythymidylate, 5-Fluoro Uracil-DNA damage
• C. Methotrexate-DNA damage, Vinca alkaloids-RNA damage, Bleomycin-Inhibition of Purine synthesis, 5- Fluoro Uracil-Inhibition of 2 deoxythymidylate
• D. Methotrexate-Inhibition of Purine synthesis, Vinca alkaloids-Inhibition of Microtubules, Bleomycin-DNA damage, 5-Fluoro Uracil-inhibition of 2-deoxythmidylate

Answer 1

The Correct Option is D

To determine the correct match or mechanisms among the given options, we need to examine the mechanisms of action of each drug:

1. Methotrexate: Methotrexate is a chemotherapy agent and immune system suppressant. It inhibits the enzyme dihydrofolate reductase, which is crucial for the synthesis of purines and pyrimidines, thus affecting nucleic acid synthesis. Therefore, it primarily results in the inhibition of purine synthesis.
2. Vinca Alkaloids: Vinca alkaloids, such as vincristine and vinblastine, disrupt the assembly of microtubules, thereby inhibiting cell division. So, their mechanism is the inhibition of microtubules.
3. Bleomycin: Bleomycin binds to DNA strands, causing breaks in the DNA. This is classified as DNA damage. It is not primarily involved in RNA inhibition.
4. 5-Fluoro Uracil (5-FU): 5-Fluoro Uracil interferes with the synthesis of DNA. It targets the thymidylate synthase enzyme, reducing the production of thymidine, which is necessary for DNA synthesis. Thus, it leads to the inhibition of 2-deoxythymidylate synthesis.

With these mechanistic insights for each drug, the correct option is:

• Methotrexate-Inhibition of Purine synthesis, Vinca alkaloids-Inhibition of Microtubules, Bleomycin-DNA damage, 5-Fluoro Uracil-inhibition of 2-deoxythmidylate.