Question

_______ of tablets weighing less than 650 mg are required for friability test as per Indian Pharmacopoeia 2018.

• A. \( 10 \text{ numbers} \)
• B. \( 20 \text{ numbers} \)
• C. \( 6.5 \text{ grams} \)
• D. \( 3.25 \text{ grams} \)

Hint:

Remember that for friability testing, the quantity of tablets is determined by their total weight, aiming for around 6.5 grams as per IP 2018.

Answer 1

The Correct Option is C

According to the Indian Pharmacopoeia 2018 guidelines for the friability test, a sample of tablets having a total weight as close as possible to 6.5 g is used. For tablets weighing less than 650 mg each, a number of tablets corresponding to approximately 6.5 g is taken. For example, if each tablet weighs 325 mg, then 20 tablets would be used. Therefore, the requirement is based on the total weight of the tablets, aiming for 6.5 grams.