Question

Myasthenia gravis is an autoimmune disease where the patient makes antibodies for its own:

• A. Acetylcholine receptor protein
• B. NOD1 protein
• C. TLR11 protein
• D. RIG-I protein

Hint:

In Myasthenia gravis, the immune system attacks the acetylcholine receptors on muscle cells, causing muscle weakness and fatigue. The disease is a classic example of an autoimmune disorder.

Answer 1

The Correct Option is A

Step 1: Understand Myasthenia Gravis.
Myasthenia gravis is an autoimmune neuromuscular disorder. In this condition, the immune system produces antibodies that interfere with the communication between nerves and muscles, causing weakness and fatigue in skeletal muscles.

Step 2: Evaluate the options:

• Acetylcholine receptor protein: Correct. This is the primary target in Myasthenia gravis. Autoantibodies block or destroy acetylcholine receptors at the neuromuscular junction, preventing effective signal transmission.
• NOD1 protein: Involved in detecting bacterial components and activating innate immunity. Not involved in Myasthenia gravis.
• TLR11 protein: A toll-like receptor involved in pathogen recognition, primarily in mice. Not related to Myasthenia gravis.
• RIG-I protein: A receptor involved in recognizing viral RNA. Not associated with Myasthenia gravis.

Step 3: Conclusion.
The correct target of autoantibodies in Myasthenia gravis is the Acetylcholine receptor protein.

Correct Answer: Option (1)