Question

Multidrug-resistant (MDR) tuberculosis shows resistance to which of the following drugs?

• A. Isoniazid, rifampicin, and fluoroquinolone
• B. Fluoroquinolones
• C. Isoniazid and rifampicin
• D. Isoniazid, rifampicin, and kanamycin

Answer 1

The Correct Option is C

Multidrug-resistant (MDR) tuberculosis (TB) is a form of tuberculosis infection caused by bacteria that are resistant to treatment with at least two of the most potent TB drugs. These drugs are:

• Isoniazid
• Rifampicin

Resistance to both of these drugs defines MDR-TB. It is a serious public health challenge and complicates treatment regimens substantially, often requiring the use of second-line drugs.

The options provided for MDR-TB resistance include:

• Isoniazid, rifampicin, and fluoroquinolone
• Fluoroquinolones
• Isoniazid and rifampicin
• Isoniazid, rifampicin, and kanamycin

Among these options, the correct answer is:

Isoniazid and rifampicin

This distinction is crucial for understanding TB treatment guidelines and for public health responses to combat drug resistance.