Question

Most common mutation in Papillary cell carcinoma?

• A. BRAF V600E
• B. RET
• C. MET
• D. RAS

Hint:

BRAF V600E mutation is a significant marker for papillary thyroid carcinoma and can help in diagnosis and targeted therapy.

Answer 1

The Correct Option is A

Papillary cell carcinoma, a common type of thyroid cancer, is often linked to specific genetic mutations. One of the most prevalent mutations associated with papillary cell carcinoma is the BRAF V600E mutation. This mutation leads to the substitution of valine (V) by glutamic acid (E) at codon 600 in the BRAF gene, which is part of the MAPK/ERK signaling pathway. This pathway, when mutated, can result in uncontrolled cell division and cancer. The BRAF V600E mutation is a driver mutation in papillary thyroid cancers, making it the most common mutation observed in this carcinoma.