Question

Most common indication for liver transplant in children

• A. Biliary atresia
• B. Cirrhosis
• C. Hepatitis
• D. Drug reactions

Answer 1

The Correct Option is A

In the field of pediatric pathology, understanding the most common indications for liver transplantation in children is crucial. This topic revolves around various conditions that can severely impair liver function, necessitating a transplant. Among the listed options:

• Biliary atresia
• Cirrhosis
• Hepatitis
• Drug reactions

The condition that stands out as the most prevalent cause leading to liver transplants in the pediatric population is biliary atresia.

Biliary Atresia: It is a congenital condition where the bile ducts, which carry bile from the liver to the gallbladder, are malformed or absent. This leads to bile accumulation in the liver, causing damage and ultimately liver failure if not treated early. Its frequency and severity make it the primary reason for liver transplant in children.

Comparison with Other Options:

• Cirrhosis: Although a potential cause, cirrhosis in children is often a secondary condition resulting from other liver diseases like biliary atresia.
• Hepatitis: Infections causing hepatitis can be managed with antiviral treatments and do not usually necessitate transplantation unless they lead to severe chronic liver damage.
• Drug reactions: While certain drugs can cause liver damage, such cases are less common, and alternative treatments often exist.

Conclusively, among the options provided, biliary atresia is the most common indication for liver transplantation in children, requiring early diagnosis and intervention to improve outcomes.