Question

Mechanism of resistance to penicillins via beta-lactamase is

• A. Altered penicillin-binding proteins
• B. Drug efflux
• C. Breaks drug structure
• D. Alteration in 50S ribosome structure

Answer 1

The Correct Option is C

When exploring the mechanism of resistance to penicillins via beta-lactamase, it is essential to understand the role of beta-lactamase enzymes. These enzymes are produced by certain bacteria and play a crucial role in antibiotic resistance, particularly against beta-lactam antibiotics like penicillins.

The primary mechanism by which beta-lactamase confers resistance is through the breakdown of the drug's molecular structure. Specifically, beta-lactamase enzymes hydrolyze the beta-lactam ring, a core component of penicillin's molecular structure, rendering the antibiotic ineffective. Without an intact beta-lactam ring, penicillin cannot bind to and inhibit the transpeptidase enzyme (also known as penicillin-binding protein or PBP) that is essential for bacterial cell wall synthesis. This leads to continued bacterial growth and survival despite the presence of the antibiotic.

Thus, the correct answer is:

• Breaks drug structure