Question

Mechanism of action of Oseltamivir?

• A. Protein synthesis inhibitor
• B. Thymidylate synthetase inhibitor
• C. Neuraminidase inhibitor
• D. Pyrimidine analogs

Answer 1

The Correct Option is C

Oseltamivir is a pharmacological agent known as a neuraminidase inhibitor. It is used primarily for the treatment and prevention of influenza A and B. The mechanism by which Oseltamivir works involves the following intricate processes:

1. Inhibition of Neuraminidase: The neuraminidase enzyme is crucial for the influenza virus's life cycle. It facilitates the release of new viral particles from the infected host cells by cleaving sialic acid residues, thus allowing the virus to spread.
2. Action Mechanism: Oseltamivir, upon administration, is converted into its active form, Oseltamivir carboxylate. This active form binds to the active site of the neuraminidase enzyme, thereby inhibiting its function. By preventing the cleavage of sialic acids, it hampers the virus's ability to spread to other cells.
3. Viral Proliferation Reduction: By disrupting the release of new virions, Oseltamivir reduces the overall viral load in the body. This results in attenuated disease symptoms and faster recovery times, and also helps in preventing the onset if taken prophylactically.

Therefore, the correct classification for Oseltamivir based on its mechanism of action is Neuraminidase inhibitor.