Question

Match the items in List I with items in List II: 

 

• A. A - II, B - III, C - I, D - IV
• B. A - I, B - III, C - IV, D - II
• C. A - IV, B - II, C - III, D - I
• D. A - I, B - II, C - III, D - IV

Hint:

Remember: MHC I is recognized by cytotoxic T cells (CD8+), MHC II by helper T cells (CD4+), and plasmacytoid dendritic cells are major producers of Type I interferons. TLR9 detects CpG motifs in DNA, typically from microbes.

Answer 1

The Correct Option is D

Step 1: Match A – Toll-like receptor 9
Toll-like receptor 9 (TLR9) is known for recognizing unmethylated CpG motifs, which are typically found in bacterial and viral DNA.
⟹ A - I

Step 2: Match B – T-helper cells
T-helper cells recognize antigens presented with MHC class II molecules on antigen-presenting cells (APCs). This is essential for initiating the immune response.
⟹ B - II

Step 3: Match C – T-cytotoxic cells
T-cytotoxic (CD8⁺) cells recognize antigens associated with MHC class I molecules, typically found on all nucleated cells.
⟹ C - III

Step 4: Match D – Plasmacytoid dendritic cells (pDCs)
pDCs are specialized in the rapid and massive production of Type I interferons (especially IFN-α) in response to viral infection.
⟹ D - IV