Question

\(5-HT_{2A/2C}\) antagonist used in migraine

• A. Methysergide
• B. Ketanserin
• C. Sumatriptan
• D. Rizatriptan

Hint:

Triptans (5-HT\textsubscript{1B/1D} agonists) are used for acute migraine attacks, whereas Methysergide is used for prevention.

Answer 1

The Correct Option is A

Methysergide is a serotonin receptor antagonist primarily targeting the \(5-HT_{2A}\) and \(5-HT_{2C}\) receptors. It has been used as a prophylactic treatment for migraine by preventing vasoconstriction and platelet aggregation associated with migraine attacks. - Methysergide blocks serotonin-induced vasoconstriction, thereby reducing migraine frequency. 
- Ketanserin is also a \(5-HT_{2}\) antagonist but primarily used as an antihypertensive agent. 
- Sumatriptan and Rizatriptan are \(5-HT_{1B/1D}\) receptor agonists (triptans) used for acute migraine treatment, not antagonists. 
Hence, Methysergide is the correct drug categorized as a \(5-HT_{2A/2C}\) antagonist used in migraine prophylaxis.