Question

Male not responding to O-2, diagnosis ARDS. What is the role of IL-8 in ARDS?

• A. Endothelial cell activation
• B. Requirement of neutrophil
• C. Macrophage activation
• D. Promote surfactant production

Hint:

In ARDS, IL-8 facilitates neutrophil recruitment and activation, which contributes to the progression of inflammation and tissue damage.

Answer 1

The Correct Option is B

In ARDS (Acute Respiratory Distress Syndrome), the pathophysiology involves complex interactions among various cytokines and immune cells. One of the key cytokines involved is IL-8 (Interleukin-8).

Role of IL-8:

• IL-8 is a potent chemokine known for its role in neutrophil recruitment and activation.
• It is produced by macrophages, epithelial cells, and endothelial cells primarily in response to inflammatory stimuli.
• The primary function of IL-8 in ARDS is to act as a chemoattractant for neutrophils, guiding them to areas of inflammation in the lung tissue.
• Once neutrophils are recruited, they contribute to inflammation and tissue damage by releasing enzymes and reactive oxygen species.

Given these roles, the presence and activity of IL-8 are crucial for the recruitment of neutrophils in ARDS, aligning with the correct answer option: Requirement of neutrophil.