Question

Male not responding to O-2, diagnosis ARDS. What is the role of IL-8 in ARDS?

• A. Endothelial cell activation
• B. Requirement of neutrophil
• C. Macrophage activation
• D. Promote surfactant production

Hint:

In ARDS, IL-8 facilitates neutrophil recruitment and activation, which contributes to the progression of inflammation and tissue damage.

Answer 1

The Correct Option is B

Acute Respiratory Distress Syndrome (ARDS) is a critical condition characterized by widespread inflammation in the lungs, often leading to respiratory failure. In ARDS, one of the key players involved in the inflammatory response is the cytokine Interleukin-8 (IL-8).

Role of IL-8 in ARDS: IL-8 is a potent chemokine that plays a significant role in neutrophil recruitment and activation during inflammatory responses. In the context of ARDS, IL-8 is responsible for:

• Requirement of neutrophil: It primarily functions to attract neutrophils to the site of inflammation in the lungs. Elevated levels of IL-8 are correlated with increased neutrophil accumulation in the airways and alveoli, which directly contributes to the pathology of ARDS.

Therefore, understanding IL-8's role is crucial in providing insights into the mechanisms of immune response and potential therapeutic targets for conditions like ARDS.