Step 1: Identify crop-specific diseases.
Paddy (rice) has characteristic disorders like blast, bacterial blight, sheath blight, and Khaira disease (Zn deficiency disorder specific to rice).
Step 2: Eliminate non-rice diseases.
(A) Damping off—general seedling disease across many crops, not specific/main for paddy.
(B) Mosaic disease—viral diseases typically noted in crops like sugarcane, tobacco, cucurbits; not a principal rice disease.
(D) Karnal bunt—\textit{Tilletia indica} affects wheat, not rice.
Step 3: Conclusion.
Thus, the most appropriate “main disease” for paddy among the options is Khaira disease.