Question

Loss of foot process is classical in case of ?

• A. Membranous glomerulitis
• B. Segmental glomerulosclerosis
• C. IgA nephropathy
• D. Diabetic nephropathy

Answer 1

The Correct Option is B

Loss of foot process, also known as foot process effacement, is a histological finding where the podocytes of the glomeruli lose their interdigitating structure. This is a classical finding seen in Segmental Glomerulosclerosis. In this condition, there is damage to specific segments of some glomeruli, leading to effacement of podocyte foot processes. The other conditions listed generally have different histological characteristics:

• Membranous glomerulitis: Characterized by thickening of the glomerular basement membrane due to immune complex deposition.
• IgA nephropathy: Typically presents with mesangial proliferation and IgA deposits observed on immunofluorescence.
• Diabetic nephropathy: Exhibits nodular glomerulosclerosis (Kimmelstiel-Wilson lesions) and thickening of the basement membrane.

Hence, the condition classically associated with the loss of foot process is Segmental glomerulosclerosis.