Question

Leptin receptor is primarily present in the following tissue.

• A. Hepatic
• B. Muscle
• C. Adipose
• D. Neuronal

Hint:

Leptin receptors are most concentrated in the hypothalamus, which is the brain region responsible for regulating hunger and energy expenditure.

Answer 1

The Correct Option is D

Leptin is a hormone involved in regulating body weight and energy balance. It is primarily produced by adipose tissue (fat cells), but the leptin receptor (Ob-R) is primarily found in neuronal tissues, particularly in the hypothalamus, which plays a key role in regulating food intake and energy expenditure.

Step 1: Understand the role of leptin receptors.
Leptin receptors are involved in the signaling pathways that regulate hunger and energy balance. While leptin is produced by adipose tissue, its receptors are concentrated in the neurons of the hypothalamus, where it signals the brain about the body's energy status and helps regulate appetite and energy expenditure.

Step 2: Analyze the options.

• (1) Hepatic: The liver contains leptin receptors, but it is not the primary site of leptin receptor action.
• (2) Muscle: Muscle tissue does have leptin receptors, but they are not the primary site of action.
• (3) Adipose: While adipose tissue is the primary site of leptin secretion, it does not have the highest concentration of leptin receptors.
• (4) Neuronal: The leptin receptor is primarily found in neuronal tissue, especially in the hypothalamus, where it plays a crucial role in regulating energy homeostasis.

Thus, the correct answer is Neuronal tissue (Option 4).

Step 3: Conclusion.
The leptin receptor is primarily present in neuronal tissue, particularly the hypothalamus, where it regulates energy balance and feeding behavior.