Question

Lenvatinib.

Hint:

Lenvatinib is commonly used in combination with other drugs such as everolimus to enhance its therapeutic effects.

Answer 1

Lenvatinib is a tyrosine kinase inhibitor used primarily for the treatment of thyroid cancer and renal cell carcinoma. It inhibits multiple receptor tyrosine kinases involved in angiogenesis, including VEGFR1-3, FGFR1-4, PDGFRα, and KIT, which play critical roles in tumor cell growth and survival.
Step 1: Mechanism of Action:
Lenvatinib binds to and inhibits several receptor tyrosine kinases, blocking the signals that lead to angiogenesis, a critical process for tumor growth.
Step 2: Clinical Uses:
Lenvatinib is used for the treatment of advanced thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma in certain patient populations.
Step 3: Dosage and Administration:
Lenvatinib is typically administered orally once a day, with the dose adjusted depending on the patient's response and tolerability.