We are given:
\[
I = \int \frac{4 \tan^{-1} x}{1 + x^2} \, dx
\]
Recognize that the derivative of \( \tan^{-1} x \) is \( \frac{1}{1 + x^2} \), which simplifies the integral. Therefore, we can rewrite the integral as:
\[
I = 4 \int \tan^{-1} x \, d(\tan^{-1} x)
\]
This is a standard integral whose result is \( \frac{\pi^2}{8} \).
Thus, the correct answer is \( \frac{\pi^2}{8} \).